When cell has stalled DNA replication fork, which checkpoint should be predominantly activated?
- G1/S
- G2/M
- M
- Both G2/M and M
Answer
(1) G1/S
Solution
Checkpoints of the cell cycle check the condition of the DNA before the cell is allowed to proceed.
⇒ The G1/S checkpoint checks DNA integrity and decides whether the cell will enter and continue the replication (S) phase.
∵ A stalled replication fork means that DNA replication cannot proceed normally (DNA damage or replication stress),
∴ the replication checkpoint at the G1/S transition is predominantly activated, halting the progress of the cell through S phase until the problem is repaired.
Answer: (1)