Which of the following is the least likely to be involved in establishing the three-dimensional folding of most proteins?
- Hydrogen bonds
- Electrostatic interaction
- Hydrophobic interaction
- Ester bonds
Answer
(4) Ester bonds
Solution
The three-dimensional (tertiary) folding of a protein is maintained by interactions between the side chains (R groups) of amino acids: hydrogen bonds, electrostatic (ionic) interactions, hydrophobic interactions and disulphide bonds.
⇒ Amino acids in a protein are linked by peptide bonds, and ester bonds are not formed between their side chains.
∴ Ester bonds are the least likely to be involved in protein folding.
Answer: (4)