Keeping in view the "fluid mosaic model" for the structure of cell membrane, which one of the following statements is correct with respect to the movement of lipids and proteins from one lipid monolayer to the other (described as flip-flop movement)?
- Both lipids and proteins can flip-flop
- While lipids can rarely flip-flop proteins cannot
- While proteins can flip-flop, lipids cannot
- neither lipids, nor proteins can flip-flop
Answer
(2) While lipids can rarely flip-flop proteins cannot
Solution
⇒ As per NCERT, the fluid mosaic model (Singer and Nicolson, 1972) states that the quasi-fluid nature of lipid enables lateral movement of proteins within the overall bilayer.
⇒ Transverse (flip-flop) movement from one monolayer to the other requires the polar head of a molecule to pass through the hydrophobic core of the bilayer. Small phospholipid molecules can do this only rarely (slowly, aided by flippases).
⇒ Proteins are large molecules with big hydrophilic regions, so they cannot flip-flop; they move only laterally.
∴ Lipids can rarely flip-flop, proteins cannot.
Answer: (2)