Changes in GnRH pulse frequency in females is controlled by circulating levels of
- progesterone only
- progesterone and inhibin
- estrogen and progesterone
- estrogen and inhibin.
Answer
(3) estrogen and progesterone
Solution
GnRH is secreted by the hypothalamus in pulses.
⇒ The ovarian steroid hormones, estrogen and progesterone, exert feedback on the hypothalamus.
∴ Rising estrogen (follicular phase) increases the pulse frequency, while high progesterone (luteal phase) slows it down.
∵ Inhibin acts mainly on the pituitary (FSH), not on the GnRH pulse generator.
Hence, the GnRH pulse frequency is controlled by circulating estrogen and progesterone.
Answer: (3)