Identify the incorrect statement about tertiary structure of proteins.
- They can be fibrous or globular in structure.
- The main forces that stabilize the structure are hydrogen bonding, disulphide links, van der Waals and electrostatic forces of attraction.
- The structure remains intact when exposed to pH changes.
- A linear polypeptide chain will convert to a secondary structure and then further folding of the secondary structure will convert to tertiary structure.
Answer
(3) The structure remains intact when exposed to pH changes.
Solution
(A) As per NCERT, the tertiary structure gives rise to two major molecular shapes – fibrous and globular ⇒ correct
(B) The tertiary structure is stabilised by hydrogen bonds, disulphide linkages, van der Waals and electrostatic forces of attraction ⇒ correct
(C) A change in pH disturbs the hydrogen bonds and ionic interactions; the protein uncoils and loses its 2° and 3° structure (denaturation), while the 1° structure stays intact ⇒ incorrect
(D) Polypeptide chain → coiling into secondary structure (α-helix / β-pleated sheet) → further folding into tertiary structure ⇒ correct
∴ The incorrect statement is (C).
Answer: (3)