Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?
- Cell-mediated response
- Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cells
- Humoral immune response only
- Auto-immune response
Answer
(1) Cell-mediated response
Solution
As per NCERT, the body is able to differentiate between ‘self’ and ‘non-self’, and the cell-mediated immune response (by T-lymphocytes) is responsible for graft rejection.
⇒ The rejection occurs precisely because the recipient recognises the graft as ‘non-self’.
⇒ It is neither a humoral response only nor an auto-immune response (attack on self cells).
Answer: (1)