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Molecular Basis of Inheritance · Question 129

AIPMT 2006MCQHard📈 Topic in 38% papers+4−1
1

Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis?

  1. Neomycin
  2. Erythromycin
  3. Tetracycline
  4. Streptomycin

Answer

(4) Streptomycin

Solution

∵ Streptomycin binds to the 30S subunit of the bacterial (70S) ribosome.

⇒ It distorts the decoding site, so the anticodon of the aminoacyl-tRNA cannot pair correctly with the codon of the mRNA; the codons are misread and initiation is blocked.

⇒ Erythromycin acts on the 50S subunit and blocks translocation of the growing chain.

∴ Streptomycin inhibits the interaction between tRNA and mRNA during bacterial protein synthesis.

Answer: (4)

AIPMT 2006

Keep practising — Molecular Basis of Inheritance

2

Amino acid sequence, in protein synthesis is decided by the sequence of -

  1. cDNA
  2. mRNA
  3. tRNA
  4. rRNA
AIPMT 2006
3

E. coli cells with a mutated z gene of the lac operon cannot grow in medium containing only lactose as the source of energy because -

  1. They cannot transport lactose from the medium into the cell
  2. They cannot synthesize functional -galactosidase
  3. In the presence of glucose, E. coli cells do not utilize lactose
  4. The lac operon is constitutively active in these cells
AIPMT 2005
4

Telomerase is an enzyme which is a -

  1. RNA
  2. Repetitive DNA
  3. Simple protein
  4. Ribonucleoprotein
AIPMT 2005
5

Protein synthesis in an animal cell occurs -

  1. On ribosomes present in the nucleolus as well as in cytoplasm
  2. On ribosomes present in cytoplasm as well as in mitochondria
  3. Only on the ribosomes present in cytosol
  4. Only on ribosomes attached to the nuclear envelope and endoplasmic reticulum
AIPMT 2005
6

Which one of the following makes use of RNA as a template to synthesize DNA -

  1. Reverse transcriptase
  2. DNA dependent RNA polymerase
  3. RNA polymerase
  4. DNA polymerase
AIPMT 2005
7

During transcription holoenzyme RNA polymerase binds to a DNA sequence and the DNA assumes a saddle like structure at the point. What is the sequence called?

  1. TATA box
  2. GGTT box
  3. CAAT box
  4. AAAT box
AIPMT 2005
8

Production of a human protein in bacteria by genetic engineering is possible because

  1. The human chromosome can replicate in bacterial cell
  2. The genetic code is universal
  3. Bacterial cell can carry out the RNA splicing reactions
  4. The mechanism of gene regulation is identical in humans and bacteria
AIPMT 2005
9

During replication of a bacterial chromosome DNA synthesis starts from a replication origin site and

  1. RNA primers are involved
  2. is facilitated by telomerase
  3. moves in one direction of the site
  4. moves in bi-directional way
AIPMT 2004
10

Which form of RNA has a structure resembling clover leaf ?

  1. r-RNA
  2. m-RNA
  3. t-RNA
  4. hn-RNA
AIPMT 2004
11

During transcription, if the nucleotide sequence of the DNA strand that is being coded is ATACG, then the nucleotide sequence in the mRNA would be -

  1. UAUGC
  2. TCTGG
  3. UATGC
  4. TATGC
AIPMT 2004

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