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Molecular Basis of Inheritance · Question 135

AIPMT 2005MCQEasy📈 Topic in 75% papers+4−1
1

During transcription holoenzyme RNA polymerase binds to a DNA sequence and the DNA assumes a saddle like structure at the point. What is the sequence called?

  1. TATA box
  2. GGTT box
  3. CAAT box
  4. AAAT box

Answer

(1) TATA box

Solution

The promoter is the DNA sequence where RNA polymerase binds to start transcription.

⇒ The core promoter element about 10 bp (prokaryotes, Pribnow box) or 25–30 bp (eukaryotes) upstream of the start site is the TATA box (TATAAT / TATAAAA).

⇒ When the holoenzyme binds here, the A=T rich region unwinds easily and the DNA bends into a saddle-like structure.

∴ The sequence is the TATA box.

Answer: (1)

AIPMT 2005

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2

Production of a human protein in bacteria by genetic engineering is possible because

  1. The human chromosome can replicate in bacterial cell
  2. The genetic code is universal
  3. Bacterial cell can carry out the RNA splicing reactions
  4. The mechanism of gene regulation is identical in humans and bacteria
AIPMT 2005
3

During replication of a bacterial chromosome DNA synthesis starts from a replication origin site and

  1. RNA primers are involved
  2. is facilitated by telomerase
  3. moves in one direction of the site
  4. moves in bi-directional way
AIPMT 2004
4

Which form of RNA has a structure resembling clover leaf ?

  1. r-RNA
  2. m-RNA
  3. t-RNA
  4. hn-RNA
AIPMT 2004
5

During transcription, if the nucleotide sequence of the DNA strand that is being coded is ATACG, then the nucleotide sequence in the mRNA would be -

  1. UAUGC
  2. TCTGG
  3. UATGC
  4. TATGC
AIPMT 2004
6

The following ratio is generally constant for a given species :-

  1. A+CT+G
  2. G+CA+T
  3. A+GC+T
  4. T+CG+A
AIPMT 2004
7

DNA fingerprinting refers to :-

  1. Techniques used for molecular analysis of different specimens of DNA
  2. Analysis of DNA samples using imprinting devices
  3. Molecular analysis of profiles of DNA samples
  4. Techniques used for identification of fingerprints of individuals
AIPMT 2004
8

The telomeres of eukaryotic chromosomes consist of short sequences of

  1. Adenine rich repeats
  2. Cytosine rich repeats
  3. Thymine rich repeats
  4. Guanine rich repeats
AIPMT 2004
9

What would happen if in a gene encoding a polypeptide of 50 amino acids, 25th codon (UAU) is mutated to UAA?

  1. A polypeptide of 49 amino acids will be formed
  2. A polypeptide of 25 amino acids will be formed
  3. Two polypeptides of 24 and 25 amino acids will be formed
  4. A polypeptide of 24 amino acids will be formed
AIPMT 2003
10

What does "lac" refer to in what we call the lac operon?

  1. The number 1,00,000
  2. Lac insect
  3. Lactase
  4. Lactose
AIPMT 2003
11

During translation initiation in prokaryotes, a GTP molecule is needed in:

  1. Association of 30S-mRNA with formyl-met-tRNA
  2. Formation of formyl-met-tRNA
  3. Association of 50S subunit of ribosome with initiation complex
  4. Binding of 30S subunit of ribosome with mRNA
AIPMT 2003

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