Blood analysis of a patient reveals an unusually high quantity of carboxyhaemoglobin content. Which of the following conclusions is most likely to be correct? The patient has been inhaling polluted air containing unusually high content of
- carbon disulphide
- chloroform
- carbon dioxide
- carbon monoxide.
Answer
(4) carbon monoxide.
Solution
Carboxyhaemoglobin (COHb) is formed when carbon monoxide combines with the haem of haemoglobin.
Hb + CO HbCO (carboxyhaemoglobin)
∵ The affinity of haemoglobin for CO is about 200 times its affinity for O2, inhaling air rich in CO raises the carboxyhaemoglobin level and reduces oxygen transport.
∵ CO2 combines with the amino groups of globin to form carbamino-haemoglobin, not carboxyhaemoglobin.
∴ The patient has been inhaling air with an unusually high content of carbon monoxide.
Answer: (4)