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Cell Cycle and Cell Division · Question 41

NEET 2017MCQMedium📈 Topic in 50% papers+4−1
1

Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cell. If APC is defective in a human cell, which of the following is expected to occur?

  1. Chromosomes will be fragmented.
  2. Chromosomes will not segregate.
  3. Recombination of chromosome arms will occur.
  4. Chromosomes will not condense.

Answer

(2) Chromosomes will not segregate.

Solution

APC (a ubiquitin ligase) marks securin for degradation; this frees the enzyme separase, which cleaves the cohesin holding the sister chromatids together.

⇒ As per NCERT, at the onset of anaphase the centromeres split and the chromatids separate and move to opposite poles.

∵ A defective APC cannot trigger this separation, the cell remains arrested at metaphase.

∴ The chromosomes will not segregate.

Answer: (2)

NEET 2017

Keep practising — Cell Cycle and Cell Division

2

Spindle fibres attach on to

  1. centromere of the chromosome
  2. kinetosome of the chromosome
  3. telomere of the chromosome
  4. kinetochore of the chromosome.
NEET 2016 (Phase 1)
3

Which of the following is not a characteristic feature during mitosis in somatic cells?

  1. Chromosome movement
  2. Synapsis
  3. Spindle fibres
  4. Disappearance of nucleolus
NEET 2016 (Phase 1)
4

In meiosis crossing over is initiated at

  1. zygotene
  2. diplotene
  3. pachytene
  4. leptotene.
NEET 2016 (Phase 1)
5

During cell growth, DNA synthesis takes place on

  1. S-phase
  2. G1-phase
  3. G2-phase
  4. M phase
NEET 2016 (Phase 2)
6

When cell has stalled DNA replication fork, which checkpoint should be predominantly activated?

  1. G1/S
  2. G2/M
  3. M
  4. Both G2/M and M
NEET 2016 (Phase 2)
7

Match the stages of meiosis in column I to their characteristic features in column II and select the correct option using the codes given below.

  1. (a)-(iii), (b)-(iv), (c)-(ii), (d)-(i)
  2. (a)-(i), (b)-(iv), (c)-(ii), (d)-(iii)
  3. (a)-(ii), (b)-(iv), (c)-(iii), (d)-(i)
  4. (a)-(iv), (b)-(iii), (c)-(ii), (d)-(i)
NEET 2016 (Phase 2)
8

Arrange the following events of meiosis in correct sequence (i) Crossing over (ii) Synapsis (iii) Terminalisation of chiasmata (iv) Disappearance of nucleolus

  1. (i), (ii), (iii), (iv)
  2. (ii), (iii), (iv), (i)
  3. (ii), (i), (iv), (iii)
  4. (ii), (i), (iii), (iv)
AIPMT 2015
9

A somatic cell that has just completed the S phase of its cell cycle, as compared to gamete of the same species, has

  1. twice the number of chromosomes and four times the amount of DNA
  2. four times the number of chromosomes and twice the amount of DNA
  3. twice the number of chromosomes and twice the amount of DNA
  4. same number of chromosomes but twice the amount of DNA.
AIPMT 2015 (Cancelled)
10

Select the correct option.

  1. (A) - (i); (B) - (ii); (C) - (v); (D) - (iv)
  2. (A) - (ii); (B) - (iii); (C) - (iv); (D) - (v)
  3. (A) - (ii); (B) - (i); (C) - (iii); (D) - (iv)
  4. (A) - (ii); (B) - (iii); (C) - (v); (D) - (iv)
AIPMT 2015 (Cancelled)
11

During which phase(s) of cell cycle, amount of DNA in a cell remains at 4C level if the initial amount is denoted as 2C?

  1. G0 and G1
  2. G1 and S
  3. Only G2
  4. G2 and M
AIPMT 2014

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