Molecular Basis of Inheritance

Who proposed that the genetic code for amino acids should be made up of three nucleotides?

1. Jacques Monod
2. Franklin Stahl
3. George Gamow
4. Francis Crick

Against the codon 5' UAC 3', what would be the sequence of anticodon on tRNA?

1. 5' GUA 3'
2. 5' AUG 3'
3. 5' ATG 3'
4. 5' GTA 3'

In the light of the above statements, choose the correct answer from the options given below.

1. Statement I is incorrect but Statement II is true
2. Both Statement I and Statement II are true
3. Both Statement I and Statement II are false
4. Statement I is correct but Statement II is false

Under which of the following conditions will there be no change in the reading frame of following mRNA? 5' AACAGCGGUGCUAUU 3'

1. Insertion of A and G at 4th and 5th positions respectively
2. Deletion of GGU from 7th, 8th and 9th positions
3. Insertion of G at 5th position
4. Deletion of G from 5th position

Which of the following features of genetic code does allow bacteria to produce human insulin by recombinant DNA technology?

1. Genetic code is nearly universal
2. Genetic code is specific
3. Genetic code is not ambiguous
4. Genetic code is redundant

If there are 999 bases in an RNA that codes for a protein with 333 amino acids, and the base at position 901 is deleted such that the length of the RNA becomes 998 bases, how many codons will be altered ?

1. 1
2. 11
3. 333
4. 33

Which one of the following is the starter codon ?

1. AUG
2. UAG
3. UAA
4. UGA

Which of the following is not a property of the genetic code ?

1. Ambiguous
2. Universal
3. Degeneracy
4. Non-overlapping

The one aspect which is not a salient feature of genetic code, is its being –

1. Specific
2. Degenerate
3. Ambiguous
4. Universal

Whose experiments cracked the DNA and discovered unequivocally that a genetic code is a "triplet"?

1. Nirenberg and Matthaei
2. Morgan and Sturtevant
3. Hershey and Chase
4. Beadle and Tatum

What is not true for genetic code?

1. It is nearly universal
2. A codon in mRNA is read in a noncontiguous fashion
3. It is degenerate
4. It is unambiguous

Which one of the following pairs of codons is correctly matched with their function or the signal for the particular amino acid?

1. UUA, UCA — Leucine
2. AUG, ACG — Start/Methionine
3. UAG, UGA — Stop
4. GUU, GCU — Alanine

One gene-one enzyme hypothesis was postulated by -

1. A. Garrod
2. Hershey and Chase
3. Beadle and Tatum
4. R. Franklin

Production of a human protein in bacteria by genetic engineering is possible because

1. The human chromosome can replicate in bacterial cell
2. The genetic code is universal
3. Bacterial cell can carry out the RNA splicing reactions
4. The mechanism of gene regulation is identical in humans and bacteria

Which form of RNA has a structure resembling clover leaf ?

1. r-RNA
2. m-RNA
3. t-RNA
4. hn-RNA

What would happen if in a gene encoding a polypeptide of 50 amino acids, 25th codon (UAU) is mutated to UAA?

1. A polypeptide of 49 amino acids will be formed
2. A polypeptide of 25 amino acids will be formed
3. Two polypeptides of 24 and 25 amino acids will be formed
4. A polypeptide of 24 amino acids will be formed

Which one of the following triplet codes, is correctly matched with its specificity for an amino acid in protein synthesis or as 'start' or 'stop' codon?

1. UUU – Stop
2. UAC – Tyrosine
3. UGU – Leucine
4. UCG – Start

Degeneracy of a genetic code is attributed to the:

1. Second member of a codon
2. Third member of a codon
3. First member of a codon
4. Entire codon

In the genetic code dictionary, how many codons are used to code for all the 20 amino acids:

1. 64
2. 20
3. 60
4. 61

Out of 64 codons, 61 codons code for 20 types of amino acids; it is called : -

1. Wobbling of codon
2. Universality of codons
3. Overlapping of gene
4. Degeneracy of genetic code

Which of the following is initiation codon?

1. AUC
2. CCU
3. UAG
4. AUG

Anticodon occurs in:

1. DNA
2. r-RNA
3. t-RNA
4. m-RNA

In three dimensional view the molecule of t-RNA is:

1. E-shaped
2. L-shaped
3. S-shaped
4. Y-shaped