Which of the following statements is not true for cancer cells in relation to mutations ?
- Mutations inhibit production of telomerase
- Mutations in proto-oncogenes accelerate the cell cycle
- Mutations destroy telomerase inhibitor
- Mutations inactivate the cell control
Answer
(1) Mutations inhibit production of telomerase
Solution
Cancer cells divide indefinitely; for this they must keep their telomeres long.
⇒ Mutations in cancer cells activate (not inhibit) telomerase, e.g. by destroying the telomerase inhibitor — (3) is true.
⇒ Mutations convert proto-oncogenes into oncogenes, which accelerate the cell cycle — (2) is true.
⇒ Mutations inactivate the normal cell-cycle control (contact inhibition, tumour suppressors) — (4) is true.
∴ "Mutations inhibit production of telomerase" is not true.
Answer: (1)