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Principles of Inheritance and Variation · Question 118

AIPMT 2006MCQMedium📈 Topic in 50% papers+4−1
1

Sickle cell anaemia has not been eliminated from the African population because-

  1. It is not a fatal disease
  2. It is controlled by dominant genes
  3. It is controlled by recessive genes
  4. It provides immunity against malaria

Answer

(4) It provides immunity against malaria

Solution

∵ Heterozygous carriers (HbAHbS) of the sickle-cell gene are resistant to malaria, because the malarial parasite ( Plasmodium) cannot complete its development in their red blood cells.

⇒ In malaria-prone regions of Africa, carriers survive and reproduce better than normal homozygotes.

⇒ Natural selection therefore keeps the HbS allele in the population (balanced polymorphism).

∴ Sickle cell anaemia has not been eliminated because it provides immunity against malaria.

Answer: (4)

AIPMT 2006

Keep practising — Principles of Inheritance and Variation

2

In Mendel's experiments with garden pea, round seed shape (RR) was dominant over wrinkled seeds (rr), yellow cotyledon (YY) was dominant over green cotyledon (yy). What are the expected phenotypes in the F2 generation of the cross RRYY × rryy?

  1. Round seeds with yellow cotyledons, and wrinkled seeds with yellow cotyledons
  2. Only wrinkled seeds with green cotyledons
  3. Only wrinkled seeds with yellow cotyledons
  4. Only round seeds with green cotyledons
AIPMT 2006
3

How many different kinds of gametes will be produced by a plant having the genotype AABbCC?

  1. Two
  2. Nine
  3. Four
  4. Three
AIPMT 2006
4

Phenotype of an organism is the result of-

  1. Environmental changes and sexual dimorphism
  2. Cytoplasmic effects and nutrition
  3. Genotype and environment interactions
  4. Mutations and linkages
AIPMT 2006
5

Which one of the following is an example of polygenic inheritance?

  1. Skin colour in humans
  2. Pod shape in garden pea
  3. Production of male honey bee
  4. Flower colour in Mirabilis jalapa
AIPMT 2006
6

In order to find out the different types of gametes produced by a pea plant having the genotype AaBb, it should be crossed to a plant with the genotype -

  1. aaBB
  2. aabb
  3. AaBb
  4. AABB
AIPMT 2005
7

G-6-P dehydrogenase deficiency is associated with haemolysis of -

  1. RBCs
  2. Lymphocytes
  3. Platelets
  4. Leucocytes
AIPMT 2005
8

A man and a woman, who do not show any apparent signs of a certain inherited disease, have seven children (2 daughters and 5 sons). Three of the sons suffer from the given disease but none of the daughters are affected. Which of the following mode of inheritance do you suggest for this disease?

  1. Autosomal dominant
  2. Sex-linked recessive
  3. Sex-linked dominant
  4. Sex-limited recessive
AIPMT 2005
9

A woman with 47 chromosomes due to three copies of chromosome 21 is characterized by -

  1. Superfemaleness
  2. Turner's syndrome
  3. Triploidy
  4. Down's syndrome
AIPMT 2005
10

Haemophilia is more commonly seen in human males than in human females because -

  1. This disease is due to an X-linked dominant mutation
  2. This disease is due to a Y-linked recessive mutation
  3. This disease is due to an X-linked recessive mutation
  4. A greater proportion of girls die in infancy
AIPMT 2005
11

Which of the following is not a hereditary disease?

  1. Cretinism
  2. Cystic fibrosis
  3. Haemophilia
  4. Thalassemia
AIPMT 2005

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