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Principles of Inheritance and Variation · Question 128

AIPMT 2005MCQEasy📈 Topic in 50% papers+4−1
1

Which of the following is not a hereditary disease?

  1. Cretinism
  2. Cystic fibrosis
  3. Haemophilia
  4. Thalassemia

Answer

(1) Cretinism

Solution

Cystic fibrosis (autosomal recessive), haemophilia (X-linked recessive) and thalassemia (autosomal recessive) are Mendelian disorders passed from parents to offspring.

⇒ As per NCERT, cretinism results from hyposecretion of thyroid hormones (hypothyroidism) during pregnancy or in early childhood, often due to iodine deficiency in the diet.

∴ Cretinism is a hormonal (endocrine) disorder, not a hereditary disease.

Answer: (1)

AIPMT 2005

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2

A woman with normal vision, but whose father was colour blind, marries a colour blind man. Suppose that the fourth child of this couple was a boy. This boy -

  1. May be colour blind or may have normal vision
  2. Must have normal colour vision
  3. Must be colour blind
  4. Will be partially colour blind since he is heterozygous for the colour blind mutant allele.
AIPMT 2005
3

A woman with 47 chromosomes due to three copies of chromosome 21 is characterized by

  1. triploidy
  2. Down’s syndrome
  3. superfemaleness
  4. Turner’s syndrome
AIPMT 2005
4

In a plant, red fruit (R) is dominant over yellow fruit (r) and tallness (T) is dominant over shortness (t). If a plant with RRTt genotype is crossed with a plant that is rrtt

  1. 75% will be tall with red fruit
  2. 25% will be tall with red fruit
  3. 50% will be tall with red fruit
  4. All the offspring will be tall with red fruit
AIPMT 2004
5

A male human is heterozygous for autosomal genes A and B and is also hemizygous for hemophilic gene h. What proportion of his sperms will be abh?

  1. 1/16
  2. 1/32
  3. 1/8
  4. 1/4
AIPMT 2004
6

Lack of independent assortment of two genes A and B in fruit fly Drosophila is due to

  1. Linkage
  2. Recombination
  3. Repulsion
  4. Crossing over
AIPMT 2004
7

One of the parents of a cross has a mutation in its mitochondria. In that cross, that parent is taken as a male. During segregation of F2 progenies that mutation is found in -

  1. 50% of the progenies
  2. 1/3 of the progenies
  3. None of the progenies
  4. All the progenies
AIPMT 2004
8

A normal woman, whose father was colour-blind is married to a normal man. The sons would be :-

  1. All colour-blind
  2. 75% colour-blind
  3. All normal
  4. 50% colour-blind
AIPMT 2004
9

The recessive genes located on X-chromosomes in humans are always -

  1. Expressed in females
  2. Sub-lethal
  3. Expressed in males
  4. Lethal
AIPMT 2004
10

After a mutation at a genetic locus the character of an organism changes due to the change in :-

  1. Protein synthesis pattern
  2. RNA transcription pattern
  3. DNA replication
  4. Protein structure
AIPMT 2004
11

In a mutational event, when adenine is replaced by guanine, it is a case of -

  1. Frameshift mutation
  2. Transition
  3. Transversion
  4. Transcription
AIPMT 2004

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