Study the pedigree chart given below: [figure] What does it show?
- Inheritance of a recessive sex-linked disease like haemophilia
- Inheritance of a sex-linked inborn error of metabolism like phenylketonuria
- The pedigree chart is wrong as this is not possible
- Inheritance of a condition like phenylketonuria as an autosomal recessive trait
Answer
(4) Inheritance of a condition like phenylketonuria as an autosomal recessive trait
Solution
Unaffected parents in generation I have an affected son and an affected daughter ⇒ the trait is recessive (both parents are carriers).
⇒ An affected daughter from an unaffected father rules out X-linked recessive inheritance (her father would have to be affected).
⇒ In generation III, unaffected parents again have an affected son ⇒ both are carriers.
∴ The trait is autosomal recessive, like phenylketonuria (PKU is an autosomal recessive inborn error of metabolism, not sex-linked).
Answer: (4)