Which of the following factors is responsible for the formation of concentrated urine?
- Secretion of erythropoietin by Juxtaglomerular complex.
- Hydrostatic pressure during glomerular filtration.
- Low levels of antidiuretic hormone.
- Maintaining hyperosmolarity towards inner medullary interstitium in the kidneys.
Answer
(4) Maintaining hyperosmolarity towards inner medullary interstitium in the kidneys.
Solution
As per NCERT, the proximity between Henle's loop and vasa recta and the counter current in them help in maintaining an increasing osmolarity towards the inner medullary interstitium (from 300 mOsmol L-1 in the cortex to about 1200 mOsmol L-1 in the inner medulla).
⇒ This gradient helps easy passage of water from the collecting tubule, concentrating the filtrate.
∵ Low ADH causes dilute urine, erythropoietin acts on RBC formation and glomerular hydrostatic pressure only drives filtration,
∴ hyperosmolarity of the inner medullary interstitium is responsible for concentrated urine.
Answer: (4)