Which of the metabolites is common to respiration-mediated breakdown of fats, carbohydrates and proteins?
- Pyruvic acid
- Acetyl CoA
- Glucose-6-phosphate
- Fructose-1,6-bisphosphate
Answer
(2) Acetyl CoA
Solution
As per NCERT (amphibolic pathway), carbohydrates are broken down to glucose → pyruvic acid → acetyl CoA; fats are broken down to glycerol and fatty acids, and the fatty acids are degraded to acetyl CoA; proteins are broken down to amino acids, which (after deamination) enter as pyruvic acid, acetyl CoA or Krebs cycle intermediates.
∵ Fatty acids enter respiration directly as acetyl CoA (not via pyruvic acid or the hexose phosphates),
∴ acetyl CoA is the metabolite common to the breakdown of all three.
Answer: (2)