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Principles of Inheritance and Variation · Question 104

AIPMT 2009MCQEasy📈 Topic in 50% papers+4−1
1

Sickle-cell anaemia is:

  1. Caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin
  2. An autosomal linked dominant trait
  3. Caused by a change in a single base pair of DNA
  4. Characterised by elongated sickle like RBCs with a nucleus

Answer

(3) Caused by a change in a single base pair of DNA

Solution

As per NCERT, sickle-cell anaemia is an autosomal recessive trait caused by the substitution of glutamic acid (Glu) by valine (Val) at the sixth position of the beta globin chain.

⇒ This results from a single base substitution (point mutation) in the beta globin gene: GAG → GUG.

(1) has the substitution reversed, (2) the trait is recessive, (4) human RBCs are enucleate.

Answer: (3)

AIPMT 2009

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2

The most popularly known blood grouping is the ABO grouping. It is named ABO and not ABC, because "O" in it refers to having:

  1. Other antigens besides A and B on RBCs
  2. No antigens A and B on RBCs
  3. Overdominance of this type on the genes for A and B types
  4. One antibody only – either anti-A or anti-B on the RBCs
AIPMT 2009
3

Study the pedigree chart given below: [figure] What does it show?

  1. Inheritance of a recessive sex-linked disease like haemophilia
  2. Inheritance of a sex-linked inborn error of metabolism like phenylketonuria
  3. The pedigree chart is wrong as this is not possible
  4. Inheritance of a condition like phenylketonuria as an autosomal recessive trait
AIPMT 2009
4

Which one of the following conditions in humans is correctly matched with its chromosomal abnormality/linkage?

  1. Klinefelter's syndrome — 44 autosomes + XXY
  2. Colour-blindness — Y-linked
  3. Down syndrome — 44 autosomes + XO
  4. Erythroblastosis foetalis — X-linked
AIPMT 2008
5

Haploids are more suitable for mutation studies than the diploids. This is because:

  1. all mutations, whether dominant or recessive are expressed in haploids
  2. mutagens penetrate in haploids more effectively than in diploids
  3. haploids are reproductively more stable than diploids
  4. haploids are more abundant in nature than diploids
AIPMT 2008
6

A human male produces sperms with the genotypes AB, Ab, aB, and ab pertaining to two diallelic characters in equal proportions. What is the corresponding genotype of this person?

  1. AaBb
  2. AABB
  3. AaBB
  4. AABb
AIPMT 2007
7

In pea plants, yellow seeds are dominant to green. If a heterozygous yellow seeded plant is crossed with a green seeded plant, what ratio of yellow and green seeded plants would you expect in F1 generation?

  1. 9 : 1
  2. 3 : 1
  3. 50 : 50
  4. 1 : 3
AIPMT 2007
8

Inheritance of skin colour in humans is an example of:

  1. Chromosomal aberration
  2. Polygenic inheritance
  3. Codominance
  4. Point mutation
AIPMT 2007
9

In the hexaploid wheat, the haploid (n) and basic (x) numbers of chromosomes are:

  1. n = 21 and x = 14
  2. n = 21 and x = 21
  3. n = 7 and x = 21
  4. n = 21 and x = 7
AIPMT 2007
10

A common test to find the genotype of a hybrid is by:-

  1. Crossing of one F1 progeny with recessive parent
  2. Crossing of one F2 progeny with female parent
  3. Crossing of one F2 progeny with male parent
  4. Studying the sexual behaviour of F1 progenies
AIPMT 2007
11

Both sickle cell anemia and Huntington's chorea are-

  1. Congenital disorders
  2. Bacteria-related diseases
  3. Virus-related diseases
  4. Pollutant-induced disorders
AIPMT 2006

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