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Principles of Inheritance and Variation · Question 147

AIPMT 2002MCQEasy📈 Topic in 38% papers+4−1
1

Which of the following is the example of pleiotropy ?

  1. Thalassemia
  2. Haemophilia
  3. Sickle cell anaemia
  4. Colour blindness

Answer

(3) Sickle cell anaemia

Solution

Pleiotropy: a single gene produces more than one phenotypic effect.

As per NCERT, a pleiotropic gene affects several traits; the underlying mechanism is often the effect of the gene on a metabolic pathway.

In sickle cell anaemia, a single point mutation in the β-globin gene (GAG → GUG, glutamic acid → valine at the sixth position) changes the haemoglobin, which produces many effects: sickle-shaped RBCs, anaemia, blocked capillaries, pain, damage to organs and resistance to malaria.

∴ Sickle cell anaemia is a classic example of pleiotropy; haemophilia and colour blindness show a single main effect.

Answer: (3)

AIPMT 2002

Keep practising — Principles of Inheritance and Variation

2

There are three genes a, b and c. The percentage of crossing over between a and b is 20%, b and c is 28% and a and c is 8%. What is the sequence of genes on chromosome?

  1. a, b, c
  2. b, a, c
  3. a, c, b
  4. None
AIPMT 2002
3

On selfing a plant of F1 generation with genotype “AABbCC”, the phenotypic ratio in F2 generation will be

  1. 1 : 1
  2. 3 : 1
  3. 9 : 3 : 3 : 1
  4. 27 : 9 : 9 : 9 : 3 : 3 : 3 : 1
AIPMT 2002
4

A gene is said to be dominant if : -

  1. It is expressed only in heterozygous condition
  2. It expresses its effect only in homozygous stage
  3. It is never expressed in any condition
  4. It is expressed both in homozygous and heterozygous condition
AIPMT 2002
5

A diseased man marries a normal woman. They get three daughters and five sons. All the daughters were diseased and sons were normal. The gene of this disease is : -

  1. Sex linked dominant
  2. Autosomal dominant
  3. Sex linked recessive
  4. Sex limited character
AIPMT 2002
6

Which of the following is a correct match -

  1. Sickle cell anaemia = X – Chromosome
  2. Down Syndrome = 21st Chromosome
  3. Haemophilia = Y – Chromosome
  4. Parkinson Disease = X & Y Chromosome
AIPMT 2002
7

Change in sequence of nucleotide in DNA is called as -

  1. Recombination
  2. Mutation
  3. Mutagen
  4. Translation
AIPMT 2002
8

If a diploid cell is treated with colchicine then it becomes : -

  1. Tetraploid
  2. Monoploid
  3. Diploid
  4. Triploid
AIPMT 2002
9

Two non-allelic genes produce the new phenotype when present together but fail to do so independently then it is called

  1. Polygene
  2. Complementary gene
  3. Non-complementary gene
  4. Epistasis
AIPMT 2001
10

A and B genes are linked. What shall be genotype of progeny in a cross between AB/ab and ab/ab?

  1. AABB and aabb
  2. None
  3. AaBb and aabb
  4. AAbb and aabb
AIPMT 2001
11

When dominant and recessive alleles express themselves together it is called

  1. Dominance
  2. Pseudo dominance
  3. Co-dominance
  4. Amphidominance
AIPMT 2001

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