Principles of Inheritance and Variation · Question 1

Which one of the following disorders is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule ?

1. Phenylketonuria
2. Haemophilia
3. Sickle-cell anaemia
4. Thalassemia

Match List I with List II :

1. A-I, B-IV, C-III, D-II
2. A-I, B-III, C-II, D-IV
3. A-II, B-IV, C-III, D-I
4. A-II, B-I, C-III, D-IV

What is the probability of having children with 'O' blood group, where both mother and father are heterozygous for 'A' and 'B' blood group, respectively ?

1. 0%
2. 50%
3. 25%
4. 75%

The sixth mutant codon of beta globin gene causing polymerization of Haemoglobin and change in RBC shape is .

1. CAG
2. AUG
3. GUG
4. GAG

In a population of a grasshopper species, the chromosome number of some members is 23 and some other members possess 24 chromosomes. The 23 and 24 chromosome-bearing members in this species are .

1. females and males, respectively
2. males and females, respectively
3. all males
4. all females

Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R). In the light of the above statements, choose the most appropriate answer from the options given below:

1. A is not correct but R is correct
2. Both A and R are correct and R is the correct explanation of A
3. Both A and R are correct but R is not the correct explanation of A
4. A is correct but R is not correct

For a person with blood group 'O', which of the following is not a possible combination of parents' blood group genotypes?

1. Father : IA IB and Mother : IA i
2. Father : IA i and Mother : IA i
3. Father : IA i and Mother : IB i
4. Father : IB i and Mother : IB i

Given below are two statements: In the light of the above statements, choose the correct answer from the options given below:

1. Statement I is incorrect but Statement II is correct
2. Both Statement I and Statement II are correct
3. Both Statement I and Statement II are incorrect
4. Statement I is correct but Statement II is incorrect

What is the pattern of inheritance for polygenic trait?

1. Autosomal dominant pattern
2. X-linked recessive inheritance pattern
3. Mendelian inheritance pattern
4. Non-Mendelian inheritance pattern

With the help of given pedigree, find out the probability for the birth of a child having no disease and being a carrier (has the disease mutation in one allele of the gene) in F3 generation. [figure]

1. 1/8
2. Zero
3. 1/4
4. 1/2